Professor Clemens Oliver Hanemann MD, FRCP
Head of group
- Chair of Clinical Neurobiology
- Academic lead department of neurology PHNT
- Consultant neurologist
- Associate Medical Director for R&D Plymouth Hospital NHS Trust
- Associate Professor of Neurology/Neurobiology, University Ulm
- Medical school in Hamburg, (Johns Hopkins,Harvard,Glasgow) 10/81-05/88
- MD (University of Hamburg), 1988
- CCST neurology 01/96, CCST Medical Genetics Sept. 06
- Habilitation in Neurology and Neurobiology 11/1998
Oliver is a clinical academic running a neuro-oncology clinic with long standing expertise in basic as well as clinical research. His main interest is in “benign” low grade brain tumours. His research is form bench to bedside and back. He has championed a fast track translation of new drug targets discovered in his laboratory into clinical trials. He is neurology lead for neuro-oncology in the cancer network SW. Nationally he is member of the BNOS council, the NCRI Brain tumour CSG, NCRI translational subgroup of Brain tumour CSG and the newly established neuro-oncology section of the association British Neurologists (ABN). He published regularly in highest impact journals and the PCMDs neuro-oncology research is covered by national and international media
- Childrens Tumour Foundation
- Lord Dowding Fund
Doctorate Supervision and examination
- 12 as director of studies, 3 as second supervisor.
- 4 as external examiner (incl. University Portsmouth, University Cardiff)
Journal Reviewing and review of grant application
- International journals approx 17 incl; Brain, Annals of Neurology, Int J Cancer, Brain Pathology, Neurobiology of disease, Genes, Chromosomes and Cancer, Human Molecular Genetics, Cancer Res
Granting agencies 13 incl. Telethon, Childrens Tumour Foundation, Deutsche Forschungsgemeinschaft DFG, Cancer Research UK, Association of international cancer research (AICR)
- Schulze K, Hanemann CO*, et al. (2002) Transduction of wt-merlin into human schwannomma cells decreases schwannoma cell growth and induces apoptosis. Human Molecular Genetics 11 (1) 69-76 *Corresponding author
- Sperfeld AD, Hein C, Schröder JM, Ludolph AC Hanemann CO (2002) Occurrence and characterisation of peripheral nerve involvement in Neurofibromatosis Type 2 Brain 125:996-1004
- Kämpchen K, Mielke K, Utermark T, Langmesser S, Hanemann CO (2003) Upregulation of the Rac1/JNK signalling pathway in primary human schwannoma cells, Human Molecular Genetics 12 (11): 1211-1221
- Hirokawa J, Tikoo A, Huynh J, Utermark T, Hanemann CO, Giovannini M, Xiao GH, Testa JR, Wood J, Maruta H (2004). A clue to the therapy of neurofibromatosis type 2: NF2/Merlin is a PAK1 inhibitor. Cancer Journal 10 (1): 20-6
- Utermark T, Kämpchen K, Haneman CO (2005). Reduced apotosis in Schwannomas, Brain Pathology, 15 (1): 17-22
- Hanemann CO, Kämpchen K, Kaufmann D, Krause BJ. (2005) FDG PET CT of a giant retroperitoneal Schwannoma occurring in an NF2 patient, Arch Neurology, 62: 674-5.
- Utermark T, Schubert SJA, Hanemann CO. (2005) Rearrangements of the intermediate filament GFAP in primary human schwannoma cells, Neurobiol Dis, 19:1-9
- Grönholm M, Muranen T, Hanemann CO, Utermark T, Carpen O,.2006 Merlin interacts with the cell cycle regulator Hei10, Oncogene, 25:4389-98
- Hirokawa Y, Nakajima H, Hanemann CO, Kurtz A, Frahm S, Mautner V, Maruta H (2005) Signal therapy of NF1-deficient tumor xenograft in mice by anti-PAK1 drug FK228, Cancer Biology and Therapy 4(4): 379-381
- Hanemann CO, Bartelt-Kirbach B, Diebold R, Kämpchen K, Langmesser S, Utermark T (2006). Differential gene expression between human Schwannoma and control Schwann cells, J Neuropath Apl Neurobiol, 32:605-14
- Hanemann CO, Evans DG (2006). News on the genetics, epidemiology, medical care and translational research of Schwannomas invited review J Neurol 253: 1533-41
- Flaiz C, Kämpchen K, Matthies C; Hanermann CO (2007). Actin rich protrusions and non-localised GTPase activation in merlin deficient schwannomas, JNEN, 66:608-616
- Hanemann CO (2008)Magic but treatable? Tumours due to loss of Merlin, Brain, 131:606-15
- Ammoun S, Flaiz C, Ristic N, Hanemann CO (2008) Dissecting and targeting receptor-dependent and independent Erk pathway in human schwannoma, Cancer Research, 68:5236-5245
- C. Flaiz, J Chernoff, S Ammoun, JR Peterson, CO Hanemann (2009). Regulation of Rac by PAK in schwannoma, Exp. Neurol, 218:137-144
- M Widmer, CO Hanemann J Zajicek, (2008) High concentration s of cannabinoids activate apoptosis in human U373MG glioma cells,J. Neurosci. Res, 86(14):3212-20
- C Flaiz, Utermark T, Parkinson D, Poetsch A, Hanemann CO (2008) Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells, Glia, 56:506-515
- Christine Flaiz, Sylwia Ammoun, Anja Biebl , C Oliver Hanemann (2009) Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient schwannoma, Brain Pathology, 19:27-38
- D Hilton N Ristic, CO Hanemann (2009) Activation of Erk, Akt and JNK signalling pathway in schwannomas in situ, Histopathology, 55:744-9
- S Ammoun, D Hilton, C Matthies, CO Hanemann AZD62244 (2010), a MEK inhibitor, reduces Schwannoma proliferation,Neurobiol Dis, ;37(1):141-6.
- S Ammoun CH. Cunliffe, JC. Allen, D Zagzag, CO Hanemann* and MA Karajannis (2010) EGF Receptor Family Activation and Lapatinib in Vestibular Schwannoma, Neurooncology, 12:834-43
- Li W, You L, Cooper J, Schiavon G, Zhou L, Ishii R, Pepe-Caprio A, Giovannini M, Long SB, Erdjument-Bromage H, Hanneman CO, Zhou P, Tempst P & Giancotti F (2010). Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4-DCAF1 in the Nucleus, Cell, 140:477-90
- S Ammoun and CO Hanemann New Therapeutic Approaches for merlin deficient tumours, emerging molecular targets, Nature Reviews Neurology, in press
- S Ammoun, MC Schmid, J Trainer and CO Hanemann, Evaluation of the efficiency of Imatinib and Nilotinib in the inhibition of PDGF-R- mediated ERK and AKT activation and proliferation of human schwannoma, Neurooncology, in press
- Tel: +44 (0)1752 437418
- website: www.pcmd.ac.uk
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